Klinisk Biokemi i Norden - NFKK

Glomerular filtration rate in adults : a single sample plasma

It was demonstrated that the two methods were closely related. To test the accuracy of the two methods, the results of Cl I and CI II, were compared to 51 ‐EDTA clearance calculated by means of a standard, multiple plasma sample method (Cl SM). 2013-06-15 · The infusion clearance for 51 Cr-EDTA obtained as a measure of GFR (GFR 51Cr-EDTA) was calculated from the formula: GFR (mL/min/1.73m 2) = (51 Cr-EDTA infusion rate × 1.73)/(arterial 51 Cr-EDTA × body surface area) and compared with the urinary CrCl and the estimated GFR (eGFR) from the three estimating equations. Plasma clearance of 51 Cr‐EDTA (51 Cr‐EDTA‐Cl) was described in 1967 by Garnett et al. as an alternative method to measure GFR and has been used in clinical nephrology since then. In spite of its use for almost four decades, studies comparing In‐Cl and 51 Cr‐EDTA‐Cl have either not included renal transplant recipients [ 12 - 22 ] in their population study or included only a few [ 23 ]. Renal clearance of creatinine was significantly lower than renal clearance of iohexol (p = 0.0019) and 51Cr-EDTA (p = 0.0001). There were no significant differences between the renal clearances (Clren adv) of iohexol and 51Cr-EDTA or between their plasma clearances (ClAUC-3comp).

The renal handling of 51Cr-EDTA and inulin would therefore appear to be identical. Since "Cr-EDTA is not bound by plasma proteins and is Plasma clearance of 51 Cr‐EDTA (51 Cr‐EDTA‐Cl) is an alternative method to evaluate glomerular filtration rate (GFR). This study aimed to investigate the concordance between 51 Cr‐EDTA‐Cl and renal inulin clearance (In‐Cl) in renal transplant recipients as well to determine the repeatability of 51 Cr‐EDTA‐Cl in kidney donors. Forty four kidney recipients and 22 kidney donors were enrolled. Multiple sample method. The plasma clearance of 51 Cr-EDTA for the entire group of cats ranged between 0.4 and 8.7 ml/min/kg when normalised for body weight (mean ± SD, 3.7 ± 2.5 ml/min/kg).

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as an alternative method to measure GFR and has been used in clinical nephrology since then. In spite of its use for almost four decades, studies comparing In‐Cl and 51 Cr‐EDTA‐Cl have either not included renal transplant recipients [ 12 - 22 ] in their population study or included only a few [ 23 ].

‪Erik Sjögren‬ - ‪Google Scholar‬

In Group I (n = 46), reference Cl was determined as a multiplasma sample, single-injection method (ClSM). Sixteen blood samples were drawn from 0 until 5 hr after a single intravenous injection of 51Cr-EDTA. In Group II (n = 1046), reference Cl was The reliability of a determination of the total [51Cr]EDTA plasma clearance (E) (and with it the glomerular filtration rate), by a simplified single injection method (injected dose: 4.5 muCi per kg b.w.) using capillary blood samples (0.2 ml), was investigated in twenty children.

The single-sample method for GFR >40 automated particle-enhanced nephelometric immunoassay (Dade Behring), serum creatinine by an enzymatic method (Vitros 950), and 51Cr-EDTA- clearance rate (GFR) using 51Cr-EDTA require normalizing of GFR for 51Cr-EDTA clearance method for determination of renal function in children and adults. 1 Jan 2011 The 51Cr-EDTA method is an accepted substitute of the “gold standard” Patients consented for the 51Cr-EDTA clearance results to be used. The infusion clearance for 51Cr-EDTA obtained as a measure of GFR method when validating new methods for assessing kidney function in this patient 26 Sep 2018 However, the inulin clearance method cannot be considered in urine and its renal clearance is almost identical to 51Cr-EDTA clearance. 51Cr-EDTA clearance; however, this method is laborious.
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Treatment dose is adjusted according to GFR (the lower the GFR, the smaller the dose).

There were no significant differences between the renal clearances (Clren adv) of iohexol and 51Cr-EDTA or between their plasma clearances (ClAUC-3comp).
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isotoper, exempelvis chromium-51-ethylenediaminetetraacetic acid (51Cr-EDTA) SDMA är involverat i den inflammatoriska process som pågår vid CKD. Kidney Int Suppl, : S Brochner-Mortensen, J., A simple method for the Granerus, G. and M. Aurell, Reference values for 51Cr-EDTA clearance as a measure of av I Mäkeläinen · 2003 · Citerat av 2 — 7h Prenatal Radiation exposures at diagnostic procedures: methods to identify [7] European Commission: Practical use of the concepts of clearance and 51Cr. 6,8·10-7. 1,7·10-4. 106Ru. 4,6·10-6. 8,1·10-6. 125Sb.